Publications

Present-2000

Peer-Reviewed Research Articles

Santos-Barriopedro I, Li Y, Bahl S, Seto E (2019) HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Genes & Cancer Manuscript in press.

Urdinguio RG, Lopez V, Bayón GF, Diaz de la Guardia R, Sierra MI, García-Toraño E, Perez RF, García MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez-Alvarez B, López-Larrea C, Bernal T, Colado E, Balbín M, García-Suarez O, Chiara MD, Sáenz-de-Santa-María I, Rodríguez F, Pando-Sandoval A, Rodrigo L, Santos L, Salas A, Vallejo-Díaz J, C Carrera A, Rico D, Hernández-López I, Vayá A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Cañal MJ, Pisano D, Graña-Castro O, Thomas T, Voss AK, Menéndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF (2019) Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment. Nucleic Acids Res 47, 5016-5037.

Emmons MF, Faião-Flores F, Sharma R, Thapa R, Messina JL, Becker JC, Schadendorf D, Seto E, Sondak VK, Koomen JM, Chen YA, Lau E, Wan L, Licht JD, Smalley KSM (2019) HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy. Cancer Res 79, 2947-2961.

Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H (2019) HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proc Natl Acad Sci 116, 5487-5492.

Hu M, Armstrong N, Seto E, Li W, Zhu F, Wang PC, Tang Q (2019) Sirtuin 6 attenuates Kaposi’s sarcoma–associated herpesvirus reactivation by suppressing ori-lyt activity and expression of RTA. J Virol 93, e02200-18.

Ling H, Peng L, Wang J, Rahhal R, Seto E (2018) Histone deacetylase SIRT1 targets Plk2 to regulate centriole duplication. Cell Reports 25, 2851-2865.

Sun L, Telles E, Karl M, Cheng F, Luetteke N, Sotomayor EM, Miller RH, Seto E (2018) Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model. Life Sci Alliance 1, e201800039.

Sun L, Marin de Evsikova C, Bian K, Achille A, Telles E, Pei H, Seto E (2018) Programming and regulation of metabolic homeostasis by HDAC11. EBioMedicine 33, 157-168.
(Commentary: Bhaskara S (2018) Histone deacetylase 11 as a key regulator of metabolism and obesity. EBioMedicine 35, 27-28.)

Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. (2018) HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI Insight 3, e120159.

Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM (2017) T-cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood 130, 146-155.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW (2017) Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep 7, 8626.

Sahakian E, Chen J, Powers JJ, Chen X, Maharaj K, Deng SL, Achille AN, Lienlaf M, Wang HW, Cheng F, Sodré AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor EM, Horna P, Pinilla-Ibarz J (2017) Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology. J Leukoc Biol 102, 475-486.

Sotolongo A, Monica FZ, Kots A, Xiao H, Liu J, Seto E, Bian K, Murad F (2016) Epigenetic Regulation of soluble guanylate cyclase (sGC)β1 in Breast Cancer Cells. FASEB J 30, 3171-3180.

Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA, Lu J (2016) MOF acetylates the histone demethylase LSD1 to suppress epithelial-to-mesenchymal transition. Cell Rep 15, 2665-2678.

Lienlaf M, Perez-Villarroel P, Knox T, Pabon M, Sahakian E, Powers J, Woan KV, Lee C, Cheng F, Deng S, Smalley KS, Montecino M, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Seto E, WeberJ, Sotomayor EM, Villagra A (2016) Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Mol Oncol 10, 735-750.

Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA, Lu J (2016) MOF acetylates the histone demethylase LSD1 to suppress epithelial-to- mesenchymal transition. Cell Rep 15, 2665-2678.

Sotolongo A, Monica FZ, Kots A, Xiao H, Liu J, Seto E, Bian K, Murad F (2016) Epigenetic Regulation of soluble guanylate cyclase (sGC)β1 in Breast Cancer Cells. FASEB J 30, 3171-3180.

Zhang L, Liu S, Liu N, Zhang Y, Liu M, Li D, Seto E, Yao TP, Shui W, Zhou J (2015) Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.Protein Cell 6, 42-54. J Biol Chem 290, 8904-8912.

Wu M, Seto E, Zhang J (2015) E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.Oncotarget 6,11252-11263.

Radhakrishnan R, Li Y, Xiang S, Yuan F, Yuan Z, Telles E, Fang J, Coppola D, Shibata D, Lane WS, Zhang Y, Zhang X, Seto E (2015) Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2. J Biol Chem 290, 22795-22804.

Hernandez JM, Elahi A, Clark W, Humphries LA, Wang J, Achille A, Seto E, Shibata D (2015) The tumor suppressive effects of HPP1 are mediated via JAK-STAT-interferon signaling pathways. DNA Cell Biol 34, 541-549.

Sun L, Kokura K, Izumi V, Koomen JM, Seto E, Chen J, Fang J (2015) MPP8 and SIRT1 crosstalk in E- cadherin gene silencing and epithelial-mesenchymal transition. EMBO Rep 16, 689-699.

Li Y, Peng L, Seto E (2015) Histone deacetylase 10 regulates the cell cycle G2/M phase transition via a novel Let-7-HMGA2-cyclin A2 pathway. Mol Cell Biol 35, 3547-3565.

Sahakian E, Chen J, Powers J, Chen X, Maharaj K, Deng S, Lienlaf-Moreno M, Wang HW, Sodré AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor E, Horna P, Pinilla-Ibarz J (2015) Essential regulatory role for histone deacetylase 11 (HDAC11) in neutrophil function. J Leuk Biol Manuscript under review.

Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KS, Bergman J, Seto E, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Celis E, Weber J, Sotomayor EM, Villagra A (2015) Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation. Mol Oncol 9, 1447-1457.

Contreras PS, Gonzalez-Zuniga M, Gonzalez-Hodar L, Yanez MJ, Dulcey A, Marugan J, Seto E, Alvarez AR, Zanlungo S (2015) Neuronal gene repression in Niemann-Pick type C models is mediated by the c- Abl/HDAC2 signaling pathway. Biochim Biophys Acta 1859, 269-279.

Monteiro JB, Colón-Díaz M, Garcia M, Gutierrez S, Colón M, Seto E, Laboy J, Flores I (2014) Endometriosis is characterized by a distinct pattern of histone 3 and histone 4 lysine modifications. Reprod Sci 21, 305-318.

Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X (2014) HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular Cell 55, 31-46.

Guan D, Lim JH, Peng L, Liu Y, Lam M, Seto E, Kao HY (2014) Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. Cell Death Dis 5, e1340.

Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, A (2014) Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol 60, 44-53.

Li J, Chen S, Cleary RA, Wang R, Gannon OJ, Seto, E, Tang DD (2014) Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues. Am J Physiol Cell Physiol 307, 288-295.

Wang J, Elahi A, Ajidahun A, Clark W, Hernandez J, Achille A, Hao JH, Seto E, Shibata D (2014) The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther 15, 1198-1207.

Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, Villagra A, Sotomayor EM (2014) A novel role for histone deacetylase 6 (HDAC6) in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol 193, 2850-2862.

Gonzalez-Zuniga M, Contreras PS, Estrada LD, Chamorro D, Villagra A, Zanlungo S, Seto E, Alvarez AR (2014) c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer’s disease. Molecular Cell 56, 163-173.

Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J (2013) Regulation of SirT1- nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Mol Cell Biol 33, 3835-3848.

Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, Lienlaf M, Atadja P, Seto, E, Weber J, Sotomayor EM, Villagra A (2013) The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity. Melanoma Res 23, 341-348.

Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J (2013) hMOF Acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. Mol Cell Biol 33, 4960-4970.

Zhang X, Chen X, Lin J, Lwin T, Wright G, Moscinski LC, Dalton WS, Seto E, Wright K, Sotomayor E, Tao J (2012) Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. Oncogene 31, 3002-3008.

Colon-Diaz M, Baez-Vega P, Garcia M, Ruiz A, Monteiro JB, Fourquet J, Bayona M, Alvarez- Garriga C, Achille A, Seto E, Flores I (2012) HDAC1 and HDAC2 are differentially expressed in endometriosis. Reprod Sci 19, 483-492.

Srisuttee R, Koh SS, Kim SJ, Malilas W, Boonying W, Cho IR, Jhun BH, Ito M, Horio Y, Seto E, Oh S, Chung YH (2012) Hepatitis B virus X protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase. Oncol Rep 28, 276-282.

Kahali S, Sarcar B, Prabhu A, Seto E, Chinnaiyan P (2012) Class I histone deacetylases localize to the endoplasmic reticulum (ER) and modulate the unfolded protein response. FASEB J26, 2437- 2445.

Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E (2012) SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol32, 2823-2836.

(Spotlight: SIRT1 Deacetylase Regulates Activities and Functions of Acetyltransferases. Mol Cell Biol 32, 2645.)

Liu Y, Peng L, Seto E, Huang S, Qiu Y (2012) Modulation of histone deacetylase 6 nuclear import and tubulin deacetylase activity through acetylation. J Biol Chem 287, 29168-29174.

Zhang X, Zhao X, Fiskus W, Lin J, Lwin T, Rao R, Zhang Y, Chan JC, Fu K, Marquez VE, Chen- Kiang S, Moscinski LC, Seto E, Dalton WS, Wright KL, Sotomayor E, Bhalla K, Tao J (2012) Coordinated silencing of Myc-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas. Cancer Cell 22, 506-523.

Ling H, Peng L, Seto E, Fukasawa K (2012) Suppression of centrosome duplication and amplification by deacetylases. Cell Cycle 11, 3779-3791.

Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X. Bai W (2011) Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene 30, 2207-2218.

Wang H, Cheng F, Woan K, Sahakian E, Merino O, Rock-Klotz J, Vicente-Suarez I, Pinilla- Ibarz J, Wright KL, Seto E, Bhalla K, Villagra A, Sotomayor EM (2011) Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10. J Immunol 186, 3986-3996.

Radiloff DR, Wakeman TP, Feng J, Schilling S, Seto E, Wang XF (2011) Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. Proc Natl Acad Sci 108, 6591-6596.

Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E (2011) SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol 31, 4720-4734. (Spotlight: SIRT1 modifies DNA methyltransferase 1 activities. Mol Cell Biol 31, 4647.)

Kaluza D, Kroll J, Gesierich S, Yao TP, Boon, R, Hergenreider E, Tjwa M, Rossig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C (2011) Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J 30, 4142-4156.

Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith L, Siemann D, Kladde M, Cepko C, Lu J (2011) Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci 108, 15231-15236.

Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor E, Chen J, Lane WS, Seto E (2010) The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol 30, 3004-3015.

Wong PG, Glozak MA, Cao TV, Vaziri C, Seto E, Alexandrow MG (2010) Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin. Cell Cycle 9, 4351-4363.

Yuan Z, Peng L, Radhakrishnan R, Seto E (2010) Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein. J Biol Chem 285, 39329-39338.

Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, Nguyen D, Wright KL, Atadja PW, Bhalla K, Pinilla-Ibarz J, Seto E, Sotomayor EM (2009) The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nature Immunol 10, 92-100. (News and View: Georgopoulos K (2009) From immunity to tolerance through HDAC. Nature Immunol 10, 13-14.)

Lopez-Soto A, Folgueras AR, Seto E, Gonzalez S (2009) HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. Oncogene 28, 2370-2382.

Glozak M, Seto E (2009) Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1. J Biol Chem 284, 11446-11453.

Roy S, Shor AC, Bagui TK, Seto E, Pledger WJ (2008) Histone deacetylase 5 represses the transcription of cyclin D3. J Cell Biochem 104, 2143-2154.

Joshi B, Rastogi S, Morris M, Carastro LM, DeCook C, Seto E, Chellappan SP (2007) Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 sites. Biochem J 401, 155-166.

Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS, Yu Y (2007) Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. Int J Cancer 120, 1664-1668.

Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, Wong J, Seto E, Yang XJ (2007) Histone deacetylase 3 interacts with and deacetylates MEF2 transcription factors. Mol Cell Biol 27, 1280-1295.

Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molecular Cell 27, 149-162.

Zhang X, Yuan Z, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Dent SR, Yao TP, Lane WS, Seto E (2007) HDAC6 modulates cell motility by altering the acetylation level of cortactin. Molecular Cell 27, 197-213. (Preview: Luxton GWG, Gundersen GG (2007) HDAC6-pack: Cortactin acetylation joins the brew. Dev Cell 13, 161-162.)

Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E (2007) HDAC3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. J Biol Chem 282, 35457-35470.

Lee H, Sengupta N, Villagra A, Rezai-Zadeh N, Seto E (2006) Histone deacetylase 8 safeguards the human Ever Shorter Telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. Mol Cell Biol 26, 5259-5269.

Xu Y, Sengupta PK, Seto E, Smith BD (2006) Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha 2(I) gene (COL1A2) expression. J Biol Chem 281, 9260-9270.

Khanna P, Villagra A, Kim S, Seto E, Jaroszeski M, Kumar A, Bhansali S (2006) Use of nanocrystalline diamond for microfluidic lab-on-a-chip. Diam Relat Mater 15, 2073-2077.

Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (2005) Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev 19, 827-839.

Baumeister P, Luo S, Skarnes WC, Sui G, Seto E, Shi Y, Lee AS (2005) Endoplasmic reticulum stress induction of the Grp78/BiP promoter: Activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol 25, 4529-4540.

Gao Z, Chiao P, Zhang X, Zhang X, Lazar M, Seto E, Young HA, Ye J (2005) Coactivators and corepressors of NF-kB in IkBa gene promoter. J Biol Chem 280, 21091-21098.

Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis of antileukemia activity of histone deacetylase inhibitors. J Biol Chem 280, 26729-26734.

Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ, Chen J (2005) MDM2 interaction with nuclear co-repressor KAP-1 contributes to p53 inactivation. EMBO J 24, 3279-3290.

Lee H, Rezai-zadeh N, Seto E (2004) Negative regulation of histone deacetylase 8 activity by cAMP-dependent protein kinase A. Mol Cell Biol 24, 765-773.

Zhang X, Wharton W, Yuan Z, Tsai SC, Olashaw N, Seto E (2004) Activation of the growth/differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol Cell Biol 24, 5106-5118.

Gyory I, Wu J, Fejer G, Seto E, Wright KL (2004) PRD1-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nature Immunol 5, 299-308. (News and View: Makar KW, Wilson CB (2004) Sounds of a silent Blimp-1. Nature Immunol 5, 241-242.)

Nguyen N, Zhang X, Olashaw N, Seto E (2004) Molecular cloning and functional characterization of the transcription factor YY2. J Biol Chem 279, 25927-25934.

Wen YD, Cress WD, Roy AL, Seto E (2003) Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I. J Biol Chem 278, 1841-1847.

Gyory I, Fejer G, Ghosh N, Seto E, Wright KL (2003) Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J Immunol 170, 3125-3133.

Rezai-Zadeh N, Zhang X, Namour F, Fejer G, Wen Y, Yao Y, Gyory I, Wright K, Seto E (2003) Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes Dev 17, 1019-1029.

Weiss C, Schneider S, Wagner EF, Zhang X, Seto E, Bohmann D (2003) JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J 22, 3686-3695.

Kapustin GV, Fejer G, Gronlund JL, McCafferty DG, Seto E, Etzkorn FA (2003) Phosphorus-based SAHA analogues as histone deacetylases inhibitors. Org Lett 5, 3053-3056.

Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LPT, Seto E, Davie JR, Shen CKJ (2002) NAPP2/Pex14p, a peroxisomal membrane protein is also a transcriptional corepressor. Genomics 79, 423-431.

Yang WM, Tsai SC, Wen YD, Fejer G, Seto E (2002) Functional domains of histone deacetylase-3. J Biol Chem 277, 9447-9454.

Tsai SC, Seto E (2002) Regulation of histone deacetylase 2 by protein kinase CK2. J Biol Chem 277, 31826-31833.

Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR (2002) The transcriptional repressor Sp3 is associated with CK2 phosphorylated histone deacetylase 2. J Biol Chem 277, 35783-35786.

Tussie-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL (2002) Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxb. Proc Natl Acad Sci 99, 12807-12812.

Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE (2001) RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol Cell Biol 21, 2918-2932.

Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS (2001) The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol 21, 2259-2268.

Wagner M, Brosch G, Zwerschke W, Seto E, Loidl P, Jansen-Durr P (2001) Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2. FEBS Lett 499, 101-106.

Yao YL, Yang WM, Seto E (2001) Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol 21, 5979-5991.

Yang WM, Yao YL, Seto E (2001) The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1. EMBO J 20, 4814-4825.

Franco PJ, Farooqui M, Seto E, Wei LN (2001) The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. Mol Endocr 15, 1318-1328.

Osborne A, Zhang H, Yang WM, Seto E, Blank G (2001) Histone deacetylase activity represses IFN-g inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Mol Cell Biol 21, 6495-6506.

Guo J, Casolaro V, Seto E, Yang WM, Chang C, Seminario MC, Keen JC, Georas SN (2001) Yin Yang-1 activates IL-4 gene expression in T cells. J Biol Chem 276, 48871-48878.

Wharton W, Savell J, Cress WD, Seto E, Pledger WJ (2000) Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A: Multiple alterations in the induction and activation of cyclin/CDK complexes. J Biol Chem 275, 33981-33987.

Wei LN, Hu X, Chandra D, Seto E, Farooqui M (2000) Receptor interacting protein 140 directly recruits histone deacetylases for gene silencing. J Biol Chem 275, 40782-40787.

Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E (2000) The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci 97, 7202-7207.

Juan LJ, Shia WJ, Chen MH, Yang WM, Seto E, Lin YS, Wu CW (2000) Histone deacetylases specifically down-regulate p53-dependent gene activation. J Biol Chem 275, 20436-20443.

Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW (2000) A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J Biol Chem 275, 651-656.

Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick SM, Mandel G, Glass CK, Rose DW, Rosenfeld MG (2000) Combinatorial roles of the nuclear receptor co-repressor in transcription and development. Cell 102, 753-763.

Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E (2000) Histone deacetylase interacts directly with DNA topoisomerase II. Nature Genetics 26, 349-353.

Return to top

Review Articles (Peer Reviewed)

Rahhal R, Seto E (2019) Emerging roles of histone modifications and HDACs in RNA splicing. Nucleic Acids Res 47, 4911-4926.

Woan KV, Sahakian E, Sotomayor EM, Seto E, Villagra A (2012) Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer. Immunol Cell Biol 90, 55-65.

Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR (2012) Chromosomally integrated human herpesvirus 6: questions and answers. Rev Med Virol 22, 144-155.

Telles E, Seto E (2012) Modulation of cell cycle regulators by HDACs. Front Biosci 4, 831-839.

Villagra A, Sotomayor EM, Seto E (2010) Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene 29, 157-173.

Yang XJ, Seto E (2008) Lysine acetylation: codified crosstalk with other post-translational modifications. Molecular Cell 31, 449-461.

Yang XJ, Seto E (2008) The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nature Review Mol Cell Biol 9, 206-218.

Glozak M, Seto E (2007) Histone deacetylase and cancer. Oncogene 26, 5420-5432.

Glozak M, Sengupta N, Zhang X, Seto E (2005) Acetylation and deacetylation of non-histone proteins. Gene 363, 15-23. (One of the most cited GENE articles in the last decade)

Yang XJ, Seto E (2003) Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr Opin Genet Dev 13, 143-153.

Cress WD, Seto E (2000) Histone deacetylase, transcriptional control, and cancer. J Cell Physiol 184, 1-16.

Return to top

 

Book Chapters, Reviews, and Editorials (Non-Peer Reviewed)

Li Y, Seto E (2016) HDACs and HDAC inhibitors in cancer development and therapy. In: C Vakoc, S Henikoff, SA Armstorng (eds.) Cancer and Chromatin. Cold Spring Harbor Laboratory Press. Manuscript in Press.

Villagra A, Sahakian E, Seto E (2016) Preparation and biochemical analysis of classical histone deacetylases. Meth Enzymol 573, 161-181.

Peng L, Yuan Z, Seto E (2015) Histone deacetylase activity assay. Methods Mol Biol 1288, 95-108.

Seto E, Yoshida M (2014) Erasers of histone acetylation: The histone deacetylase enzymes. In: CD Allis, ML Caparros, T Jenuwein, D Reinberg (eds.) Epigenetics. Cold Spring Harb Perspect Biol. Cold Spring Harbor Laboratory Press. pp.143-168.>

Woods DM, Lienlaf-Moreno M, Sotomayor E, Seto E, Villagra A (2013) Regulation of the Jak/STATs pathways by histone deacetylases. In: R Kumar (ed) Nuclear Signaling Pathways and Targeting Transcription in Cancer. Humana Press, pp. 155-187.

Seto E (2013) Monographs editor. Genes Cancer 4, 75.

Yao TP, Seto E (2011) The discovery of histone deacetylase. Handb Exp Pharmacol 206:v.

Peng L, Seto, E (2011) Deacetylation of non-histone proteins by HDACs and the implications in cancer. In: TP Yao, E Seto (eds.) Histone Deacetylases: the Biology and Clinical Implication. Handbook of Experimental Pharmacology 206, 39-56.

Seto E, Yang XJ (2010) Regulation of histone deacetylase activities and functions by phosphorylation and dephosphorylation. In: RA Bradshaw, EA Dennis (eds.) Handbook of Cell Signaling, Second Edition. Elsevier Science. Chapter 286, pp. 2379-2388.

Yuan Z, Rezai-Zadeh N, Zhang X, Seto E (2009) Histone deacetylase activity assay. Methods Mol Biol 523, 279-293.

Ellis DJP, Yuan Z, Seto E (2008) Determination of protein lysine deacetylation. In: JE Coligan, BM Dunn, HL Ploegh, DW Speicher, PT Wingfield (eds.) Current Protocols in Protein Science. John Wiley & Sons, Inc. 54, 14.12.1-14.12.14.

Yuan Z, Seto E (2007) A functional link between SIRT1 deacetylase and NBS1 in DNA damage response. Cell Cycle 6, 2869-2871.

Yang XJ, Seto E (2007) HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene 26, 5310-5318.

Seto E (2006) The Biology of HDAC3. In: EM Verdin (ed.) Histone Deacetylases: Transcriptional regulation and other cellular functions. Humana Press, Totowa, New Jersey. pp. 61-86.

Sengupta N, Seto E (2004) Regulation of histone deacetylase activities. J Cell Biochem 93, 57-67.

Rezai-Zadeh N, Tsai SC, Wen YD, Yao YL, Yang WM, Seto E (2004) Histone deacetylases: Purification of the enzymes, substrates, and assay conditions. Meth Enzymol 377, 167-179.

Seto E (2003) Histone Modifications. Methods 31, 1-2.

Return to top

 

 

1999-Earlier

Peer-Reviewed Research Articles

Tang CM, Westling J, Seto E (1999) Trans-repression of the human metallothionein IIA gene promoter by PZ120, a novel 120 kilodalton zinc finger protein. Mol Cell Biol 19, 680-689.

Sasaki S, Lesoon-Wood LA, Dey A, Kuwata T, Weintraub BD, Humphrey G, Yang WM, Seto E, Yen PM, Howard BH, Ozato K (1999) Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin-beta gene. EMBO J 18, 5389-5398.

Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE (1999) RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol 19, 6632-6641.

McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein, GS (1998) Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. J Cell Biochem 68, 500-510.

Yao YL, Dupont B, Ghosh S, Fang Y, Leach RJ, Seto E (1998) Cloning, chromosomal localization, and promoter analysis of the human transcription factor YY1. Nucl Acids Res 26, 3776-3783.

Azizan A, Cong YS, Shain K, Tsai SC, Yao YL, Olashaw N, Seto E (1998) Transactivation by expression of the hepatitis B virus X protein with an inducible system. Mol Biol Rep 25, 231-236.

Zeng Y, Tang CM, Yao YL, Yang WM, Seto E (1998) Cloning and characterization of the mouse histone deacetylase-2 gene. J Biol Chem 273, 28921-28930.

Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, Davie JR, Huynh KD, Bardwell VJ, Lavinsky RM, Rosenfeld MG, Glass C, Seto E, Hiebert SW (1998) ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 18, 7176-7184.

Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E (1997) The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein. J Biol Chem 272, 16482-16489.

Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (1997) Histone deacetylases associated with the mSIN3 corepressor mediate mad transcriptional repression. Cell 89, 349-356.

Heinzel T, Lavinsky RM, Mullen TM, Soderstrom M, Laherty CD, Torchia J, Yang WM, Brard G, Ngo SD, Davie JR, Seto E, Eisenman RN, Rose DW, Glass CK, Rosenfeld MG (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387, 43-48.

Soderstrom M, Vo A, Heinzel T, Lavinsky RM, Yang WM, Seto E, Peterson DA, Rosenfeld MG, Glass CK (1997) Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes. Mol. Endocr 11, 682-692.

Yang WM, Yao YL, Sun JM, Davie JR, Seto E (1997) Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272, 28001-28007.

Adrian GS, Seto E, Fischbach KS, Rivera EV, Adrian EK, Herbert DC, Walters CA, Weaker FW, Bowman BH (1996) YY1 and Sp1 transcription factors bind the human transferrin gene in an age-related manner. J Gerontol 51, 66-75. (Winner of the 1996 Geron Corporation/Samuel Goldstein Distinguished Publication Award).

Ghosh S, Toth C, Peterlin BM, Seto E (1996) Activation features of VP16 when tethered to RNA: Implications for role in transcription elongation. J Biol Chem 271, 9911-9918.

Tang CM, Tomkinson AE, Lane WS, Wold MS, Seto E (1996) Replication protein A is a component of a complex that binds the human metallothionein IIA gene transcription start site. J Biol Chem 271, 21637-21645.

Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci 93, 12845-12850.

Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (1996) XAP2, a novel hepatitis B virus X- associated protein that inhibits X transactivation. Nucl Acids Res 24, 4741-4750.

Lewis BA, Tullis G, Seto E, Horikoshi N, Weinmann R, Shenk T (1995) Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J Virol 69, 1628-1636.

Yang WM, Inouye CJ, Seto E (1995) Cyclophilin A and FKBP12 interacts with YY1 and alters its transcriptional activity. J Biol Chem 270, 15187-15193.

Inouye CJ, Seto E (1994) Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23. J Biol Chem 269, 6506-6510.

Seto E, Lewis B, Shenk T (1993) Interaction between transcription factors Sp1 and YY1. Nature 365, 462-464.

Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T (1992) Wild- type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci 89, 12028-12032.

Seto E, Yen TSB (1991) Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans-activator. J Virol 65, 2351-2356.

Shi Y, Seto E, Chang LS, Shenk T (1991) Transcriptional repression by YY1, a human GLI-krüppel- related protein, and relief of repression by adenovirus E1A protein. Cell 67, 377-388.

Seto E, Shi Y, Shenk T (1991) YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature 354, 241-245.

Seto E, Mitchell PJ, Yen TSB (1990) Trans-Activation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344, 72-74.

Seto E, Peterlin BM, Yen TSB (1989) Trans-Activation by the hepatitis B virus X protein shows cell type specificity. Virology 173, 764-766.

Seto E, Yen TSB, Peterlin BM, Ou JH (1988) Trans-Activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci 85, 8286- 8290.

Yen TSB, Wang YF, Seto E (1988) DNA transfection into suspension cell lines with a modified calcium phosphate precipitate method. BioTechniques 6, 413-416.

Seto E, Yen TSB (1987) Detection of cytomegalovirus infection by means of DNA isolated from paraffin-embedded tissues and dot hybridization. Am J Pathol 127, 409-413.

Return to top

Review Articles (Peer Reviewed)

Thomas MJ, Seto E (1999) Unlocking the mechanisms of transcription factor YY1: Is chromatin modifying enzymes the key? Gene 236, 197-208.

Book Chapters, Reviews, and Editorials (Non-Peer Reviewed)

Yen TSB, Mitchell PJ, Seto E (1991) Mechanism of transcriptional trans-activation by the hepatitis B virus X protein. In: FB Hollinger, SM Lemon, HS Margolis (eds.) Viral Hepatitis and Liver Disease: Contemporary Issues and Future Prospects. Williams and Wilkins, Baltimore. pp. 186-189.