Welcome

Histone deacetylases (HDACs) were originally defined as a family of enzymes that catalyze the removal of acetyl groups from lysine residues of histones. The Seto lab is devoted to working towards obtaining a complete understanding of the functions, mechanisms of action, and regulation of HDACs, which play pivotal roles in the regulation of gene expression and are indispensable in numerous biological processes. Our current research examines the biological consequences of protein deacetylation, as well as non-acetyl deacylation, by HDACs. Additionally, we seek to understand the molecular mechanisms by which HDAC inhibitors alter protein expressions and functions in both normal and cancer cells.